Literature Compendium

Instant access to nine peer-reviewed studies on mTBI and CT imaging.

Discover nine research summaries that demonstrate how FDA-cleared blood-based biomarkers can aid in the management of mild traumatic brain injuries (mTBI).

TBI Literature Compendium

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A COLLECTION OF Clinical References for MTBI

Access a curated collection of peer-reviewed research essential for FDA-cleared blood based biomarkers and ED workflow.

WHAT'S IN THE COMPENDIUM?

  • Peer reviewed studies evaluating TBI biomarker performance, temporal profiles and characteristics.1-4
  • Literature examining the impact of CT imaging on mTBI management and ED workflows.5,6
  • A detailed analysis on the potential cost effectiveness of TBI biomarkers.7
  • Evidence based recommendations supporting the use of TBI biomarkers in clinical practice.8,9

References

  1. Bazarian J, et al. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. The Lancet Neurology. 2018;17(9): doi:10.1016/S1474-4422(18)30231-X.
  2. Papa L, et al. Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury. JAMA Neurol. 2016 May 01; 73(5): 551-560. doi:10.1001/jamaneurol.2016.0039.
  3. Papa L, et al. Sex Differences in Time Course and Diagnostic Accuracy of GFAP and UCH-L1 in Trauma Patients with Mild Traumatic Brain Injury. Sci Rep. 2023 Jul 14; 13(11833). doi:https://doi.org/10.1038/s41598-023-38804-4.
  4. Ward M, et al. Predictive Performance of Traumatic Brain Injury Biomarkers in High-Risk Elderly Patients. J Appl Lab Med. 2020; 5(1):91-100. doi:https://doi.org/10.1093/jalm.2019.031393.
  5. Michelson EA, et al. Emergency Department Time Course for Mild Traumatic Brain Injury Workup. West J Emerg Med. 2018;19(4):635-640. doi:10.5811/westjem.2018.5.37293.
  6. Rogg J, et al. Describing wait time bottlenecks for ED patients undergoing head CT. The American Journal of Emergency Medicine. 2017;35(10):1510-1513. doi:https://doi.org/10.1016/j.ajem.2017.04.059.
  7. YouRong Sophie Su, et al. Cost-Effectiveness of Biomarker Screening for Traumatic Brain Injury. J Neurotrauma. 2019 Jun 27;36(13):2083-2091. doi:10.1089/neu.2018.6020.
  8. Committee on Trauma, American College of Surgeons. TQP Best Practice Guidelines: The Management of Traumatic Brain Injury. Chicago, IL, 2024.
  9. Backus BE, et al. Consensus paper on the assessment of adult patients with traumatic brain injury with Glasgow Coma Scale 13-15 at the emergency department: A multidisciplinary overview. Eur J Emerg Med. 2024 Aug 1;31(4):240-249. doi: 10.1097/MEJ.0000000000001140.
  10. Dewan MC, et al. Estimating the global incidence of traumatic brain injury. J Neurosurg. 2018;130(4):1080-1097. doi:10.3171/2017.10.JNS17352